Crossref · Wavefront propagation in a hyperbolic model of hantavirus infection · 1s agoCrossref · Could bradykinin pathway inhibition change the course of severe hantavirus disease? · 1s agoCrossref · Outbreak at Sea: The MV Hondius Hantavirus Cluster as a Sentinel for Global Pandemic Readiness · 1s agoCrossref · Microbe snapshots: Hantavirus (Sin Nombre) · 1s agoCrossref · Hantavirus on the rise: clinical, virological, immunological, and public health perspectives · 1s agoCrossref · Pregnancy and hantavirus infection: maternal, fetal, and neonatal outcomes − a systematic review · 1s agoCrossref · Emerging threat of hantavirus infection: Public health challenges during an international cruise ship outbreak · 1s agoCrossref · “Hantavirus at sea: Why cruise ships must be ready for animal-borne disease.” · 1s agoCrossref · Wavefront propagation in a hyperbolic model of hantavirus infection · 1s agoCrossref · Could bradykinin pathway inhibition change the course of severe hantavirus disease? · 1s agoCrossref · Outbreak at Sea: The MV Hondius Hantavirus Cluster as a Sentinel for Global Pandemic Readiness · 1s agoCrossref · Microbe snapshots: Hantavirus (Sin Nombre) · 1s agoCrossref · Hantavirus on the rise: clinical, virological, immunological, and public health perspectives · 1s agoCrossref · Pregnancy and hantavirus infection: maternal, fetal, and neonatal outcomes − a systematic review · 1s agoCrossref · Emerging threat of hantavirus infection: Public health challenges during an international cruise ship outbreak · 1s agoCrossref · “Hantavirus at sea: Why cruise ships must be ready for animal-borne disease.” · 1s ago
US · Americas

Hantavirus in United States.

The United States has reported fewer than 900 confirmed HPS cases since surveillance began in 1993 (CDC NNDSS).

HPSSin Nombre (with Bayou and Black Creek Canal locally)CFR 30–38%
Strain
Sin
Syndrome
HPS
CFR
30–38%

The United States has reported fewer than 900 confirmed HPS cases since surveillance began in 1993 (CDC NNDSS). Cases concentrate in the Four Corners region — New Mexico, Arizona, Colorado, and Utah — driven by Sin Nombre virus and its deer-mouse reservoir. Outbreaks correlate with wet winters that increase rodent populations the following spring. National notification is mandatory; CDC publishes weekly counts via NNDSS. The 2012 Yosemite National Park outbreak (10 cases, 3 deaths from canvas-tent cabin exposure) is the most-cited US tourism-linked event. Bayou virus accounts for the majority of cases in Louisiana and the Gulf Coast.

DOMINANT STRAIN
Sin Nombre (with Bayou and Black Creek Canal locally)
SYNDROME
HPS
CASE FATALITY
30–38%
RODENT RESERVOIR
Deer mouse (Peromyscus maniculatus) in the Southwest; rice rat (Oryzomys palustris) in the Southeast; cotton rat (Sigmodon hispidus) in the South.

Active and recent clusters

  • United States · Four Corners endemic zone — 17 cases, 0 deaths (CFR 0%) · CDC NNDSS, 2026 MMWR week 17 (most recent published). United States reports approximately 15–40 confirmed HPS cases per year, concentrated in the Four Corners region (Sin Nombre virus). Numbers shown are the most recent CDC NNDSS Weekly publication.

Authoritative sources

Frequently asked

Is hantavirus a problem in United States?

Yes. United States is part of the Americas hantavirus surveillance footprint, with the Sin Nombre (with Bayou and Black Creek Canal locally) strain causing HPS and case fatality typically 30–38%.

What rodent carries hantavirus in United States?

Deer mouse (Peromyscus maniculatus) in the Southwest; rice rat (Oryzomys palustris) in the Southeast; cotton rat (Sigmodon hispidus) in the South.

Who tracks hantavirus cases in United States?

CDC — Hantavirus surveillance; data.cdc.gov NNDSS Tables.

Related

Disclaimer. Country surveillance figures are floor estimates and reflect what national authorities publish. Always confirm with the cited sources.