Crossref · Wavefront propagation in a hyperbolic model of hantavirus infection · 1s agoCrossref · Could bradykinin pathway inhibition change the course of severe hantavirus disease? · 1s agoCrossref · Outbreak at Sea: The MV Hondius Hantavirus Cluster as a Sentinel for Global Pandemic Readiness · 1s agoCrossref · Microbe snapshots: Hantavirus (Sin Nombre) · 1s agoCrossref · Hantavirus on the rise: clinical, virological, immunological, and public health perspectives · 1s agoCrossref · Pregnancy and hantavirus infection: maternal, fetal, and neonatal outcomes − a systematic review · 1s agoCrossref · Emerging threat of hantavirus infection: Public health challenges during an international cruise ship outbreak · 1s agoCrossref · “Hantavirus at sea: Why cruise ships must be ready for animal-borne disease.” · 1s agoCrossref · Wavefront propagation in a hyperbolic model of hantavirus infection · 1s agoCrossref · Could bradykinin pathway inhibition change the course of severe hantavirus disease? · 1s agoCrossref · Outbreak at Sea: The MV Hondius Hantavirus Cluster as a Sentinel for Global Pandemic Readiness · 1s agoCrossref · Microbe snapshots: Hantavirus (Sin Nombre) · 1s agoCrossref · Hantavirus on the rise: clinical, virological, immunological, and public health perspectives · 1s agoCrossref · Pregnancy and hantavirus infection: maternal, fetal, and neonatal outcomes − a systematic review · 1s agoCrossref · Emerging threat of hantavirus infection: Public health challenges during an international cruise ship outbreak · 1s agoCrossref · “Hantavirus at sea: Why cruise ships must be ready for animal-borne disease.” · 1s ago
Strain · North America

Sin Nombre virus

Sin Nombre virus is the dominant strain in the southwestern United States, causing hantavirus pulmonary syndrome.

HPSCFR ~36%42 reported cases (12 mo baseline)
CFR
36%
Cases (12mo)
42
Syndrome
HPS

Sin Nombre virus is the dominant strain in the southwestern United States, causing hantavirus pulmonary syndrome. Reservoir: deer mouse (Peromyscus maniculatus). Cases peak in spring after wet winters that increase rodent populations.

CASE FATALITY
36%
REPORTED CASES (12 MO)
42
SYNDROME
HPS
RESERVOIR
Peromyscus maniculatus (deer mouse)

Active and recent clusters

  • United States · Four Corners endemic zone — 17 cases, 0 deaths (CFR 0%) · CDC NNDSS, 2026 MMWR week 17 (most recent published). United States reports approximately 15–40 confirmed HPS cases per year, concentrated in the Four Corners region (Sin Nombre virus). Numbers shown are the most recent CDC NNDSS Weekly publication.
  • Canada · western prairies — 4 cases, 1 deaths (CFR 25%) · Annual pattern; PHAC. Canada reports approximately 2–6 confirmed HPS cases annually, concentrated in Alberta, Saskatchewan, and British Columbia. PHAC notifiable since 1994.

Frequently asked

What does Sin Nombre virus cause?

Sin Nombre virus causes hantavirus pulmonary syndrome (HPS) with case fatality typically around 36%. Patients progress from a flu-like prodrome to acute respiratory distress.

Is Sin Nombre virus contagious between people?

No documented person-to-person transmission. Sin Nombre virus spreads via inhalation of aerosolized rodent excreta from its reservoir, Peromyscus maniculatus (deer mouse).

Where does Sin Nombre virus circulate?

Sin Nombre virus circulates primarily in North America. Its main reservoir is Peromyscus maniculatus (deer mouse).

Related

Disclaimer. Strain pages are for general information. Diagnosis and treatment decisions must be made with a qualified clinician.